Hypothalamic paraventricular nucleus differentially supports lumbar and renal sympathetic outflow in water-deprived rats
نویسندگان
چکیده
منابع مشابه
Acute inhibition of the hypothalamic paraventricular nucleus decreases renal sympathetic nerve activity and arterial blood pressure in water-deprived rats.
The present study was performed to determine whether sympathetic outflow and arterial blood pressure in water-deprived rats are dependent on the ongoing neuronal activity of the hypothalamic paraventricular nucleus (PVN). Renal sympathetic nerve activity (RSNA), mean arterial blood pressure (MAP), and heart rate were recorded in urethane-alpha-chloralose-anesthetized rats that were deprived of ...
متن کاملHypothalamic Paraventricular Nucleus Modulates Sympathetic Excitation
Aldosterone stimulates the sympathetic nervous system by binding to a select population of brain mineralocorticoid receptors (MR). These MR have an equal affinity for corticosterone that is present in substantially higher concentrations, but are held in reserve for aldosterone by activity of the enzyme 11 -hydroxysteroid dehydrogenase type 2 (11 -HSD-2), which converts corticosterone to an inac...
متن کاملSalusin-β in paraventricular nucleus increases blood pressure and sympathetic outflow via vasopressin in hypertensive rats.
AIMS Salusin-β is a bioactive peptide with peripheral hypotensive, mitogenic and pro-atherosclerotic effects. The present study was designed to determine the roles of salusin-β in the paraventricular nucleus (PVN) and its relationship with arginine vasopressin (AVP) in hypertension and sympathetic activation. METHODS AND RESULTS Renovascular hypertension was induced by two-kidney, one-clip (2...
متن کاملSalusin-b in paraventricular nucleus increases blood pressure and sympathetic outflow via vasopressin in hypertensive rats
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Salusin-b in paraventricular nucleu...
متن کاملActivation of the (pro)renin receptor in the paraventricular nucleus increases sympathetic outflow in anesthetized rats.
Previous studies have indicated that hyperactivity of brain prorenin receptors (PRR) is implicated in neurogenic hypertension. However, the role of brain PRR in regulating arterial blood pressure (ABP) is not well understood. Here, we test the hypothesis that PRR activation in the hypothalamic paraventricular nucleus (PVN) contributes to increased sympathetic nerve activity (SNA). In anaestheti...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2005
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2004.076661